PDRN Repair & Rejuvenation Essence (4ml x 6pcs)
$585.00
[Product information is for reference only. This product is not yet available for sale. Stay tuned.]
SUITABLE FOR AGED, DEHYDRATED, SENSITIVE, FRAGILE, DAMAGED SKIN AFTER PROCEDURES
Activate Cell Renewal｜Ultimate Repair, Timeless Youth
Formulated with 2100ppm high-concentration PDRN. Each microsphere is only 120nm in size and 1/800 of a pore, and carries up to 9,800 PDRN fragments. Using Supramolecular Microsphere Encapsulation Technology, PDRN is folded by peptides into nano-sized molecules and further wrapped in hyaluronic acid to form a highly stable, high-capacity 3D supramolecular microspheres. This structure effectively preserves PDRN activity while significantly enhancing skin penetration. It penetrates deep into the dermis within 1 hour, delivering active ingredients to activate the skin’s natural repair process. It helps repair damaged cells (including fibroblasts), soothe inflammation, strengthen the skin barrier, and stimulate collagen production. Laboratory tests proved 427.34% skin penetration within 1 hour; 68.72% improvement in cellular repair activity; 47.95% reduction in the appearance of fine lines after 14 days.
Formulated with 2100ppm high-concentration PDRN. Each microsphere is only 120nm in size and 1/800 of a pore, and carries up to 9,800 PDRN fragments. Using Supramolecular Microsphere Encapsulation Technology, PDRN is folded by peptides into nano-sized molecules and further wrapped in hyaluronic acid to form a highly stable, high-capacity 3D supramolecular microspheres. This structure effectively preserves PDRN activity while significantly enhancing skin penetration. It penetrates deep into the dermis within 1 hour, delivering active ingredients to activate the skin’s natural repair process. It helps repair damaged cells (including fibroblasts), soothe inflammation, strengthen the skin barrier, and stimulate collagen production. Laboratory tests proved 427.34% skin penetration within 1 hour; 68.72% improvement in cellular repair activity; 47.95% reduction in the appearance of fine lines after 14 days.
Enriched with 85% Centella Asiatica Leaf Water and Ectoin, together with multiple soothing botanical extracts, the formula creates a comprehensive calming and repairing network to relieve sensitivity and redness. Fibronectin and Pro-Xylane further support cell repair and collagen production. This lightweight, fast-absorbing essence restores firmness, plumpness and vitality to aging skin while reinforcing the skin’s moisture barrier for sensitive skin. Suitable for aged skin, mature skin, dry and sensitive skin, oily and acne-prone skin, combination skin, rosacea and post-procedure skin.
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【What is PDRN?】
PDRN (Polydeoxyribonucleotide) is a highly purified DNA fragment derived from salmon or trout seminal vesicle cells, with up to 98% structural compatibility with human DNA.
PDRN (Polydeoxyribonucleotide) is a highly purified DNA fragment derived from salmon or trout seminal vesicle cells, with up to 98% structural compatibility with human DNA.
Once delivered into the dermis, PDRN activates two key skin-repair pathways:
1. PDRN is broken down by DNase enzymes into nucleotides, which serve as essential elements for new DNA synthesis, helping support cellular repair and regeneration.
2. PDRN is also converted into adenosine, which binds to A2A receptors on fibroblasts. This stimulates the skin's natural repair mechanisms, promoting collagen production, repairing damaged cells, and helping to reduce inflammation.
1. PDRN is broken down by DNase enzymes into nucleotides, which serve as essential elements for new DNA synthesis, helping support cellular repair and regeneration.
2. PDRN is also converted into adenosine, which binds to A2A receptors on fibroblasts. This stimulates the skin's natural repair mechanisms, promoting collagen production, repairing damaged cells, and helping to reduce inflammation.
As both DNase enzymes and A2A receptors are primarily located within the dermis, PDRN must effectively penetrate to this layer to fully deliver its regenerative and skin-repair benefits.
【The Key to PDRN Efficacy: Delivery Technology】
PDRN has become a popular skin-repair ingredient in recent years. However, its efficacy depends not only on concentration, but more importantly on “stability” and “delivery technology”. Unprocessed PDRN molecules are extremely large (over 50,000 Da) and cannot effectively penetrate the stratum corneum to reach the dermis (approximately 500 Da or below is required for dermal penetration). In addition, PDRN is highly sensitive to temperature and pH changes, which can lead to degradation and loss of activity. Thus, even when high concentrations of PDRN are applied to the skin surface, without advanced penetration and delivery systems, the active ingredients cannot be effectively absorbed or utilized by the skin.
PDRN has become a popular skin-repair ingredient in recent years. However, its efficacy depends not only on concentration, but more importantly on “stability” and “delivery technology”. Unprocessed PDRN molecules are extremely large (over 50,000 Da) and cannot effectively penetrate the stratum corneum to reach the dermis (approximately 500 Da or below is required for dermal penetration). In addition, PDRN is highly sensitive to temperature and pH changes, which can lead to degradation and loss of activity. Thus, even when high concentrations of PDRN are applied to the skin surface, without advanced penetration and delivery systems, the active ingredients cannot be effectively absorbed or utilized by the skin.
The Preface PDRN Repair & Rejuvenation Essence is powered by an advanced Supramolecular Microsphere Encapsulation Technology, which integrates PDRN, peptides, and hyaluronic acid into a 3D supramolecular microsphere delivery system.
✔ Preserves PDRN activity and protects against degradation
✔ 120nm ultra-fine microspheres with over 90% absorption efficiency
✔ Delivers actives into the dermis within 1 hour
✔ Activates fibroblasts, boosts collagen production, supports cellular repair, and helps reduce sensitivity and visible ageing signs
✔ Preserves PDRN activity and protects against degradation
✔ 120nm ultra-fine microspheres with over 90% absorption efficiency
✔ Delivers actives into the dermis within 1 hour
✔ Activates fibroblasts, boosts collagen production, supports cellular repair, and helps reduce sensitivity and visible ageing signs
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【Ingredients】
Centella Asiatica Leaf Extract, Butylene Glycol, Water, Mannitol, 1,2-Hexanediol, Hydroxyacetophenone, Fibronectin, Ectoin, Trehalose, Hydroxypropyl Tetrahydropyrantriol(Pro-Xylane), 1,2-Pentanediol, Gentiana Scabra Root Extract, Panthenol(Vitamin B5), Sodium DNA, β-Glucans, Hydrolyzed Sodium Hyaluronate, Succinoglycan, Glycyrrhiza Inflata Root Extract, Sodium Polyglutamate, Sodium Hyaluronate, Dendrobium Officinale Stem Extract, Glycerol, Polylysine, Chamomilla Recutita Flower Extract, Sophora Angustifolia Root Extract, Alcaligenes Polysaccharides.
Centella Asiatica Leaf Extract, Butylene Glycol, Water, Mannitol, 1,2-Hexanediol, Hydroxyacetophenone, Fibronectin, Ectoin, Trehalose, Hydroxypropyl Tetrahydropyrantriol(Pro-Xylane), 1,2-Pentanediol, Gentiana Scabra Root Extract, Panthenol(Vitamin B5), Sodium DNA, β-Glucans, Hydrolyzed Sodium Hyaluronate, Succinoglycan, Glycyrrhiza Inflata Root Extract, Sodium Polyglutamate, Sodium Hyaluronate, Dendrobium Officinale Stem Extract, Glycerol, Polylysine, Chamomilla Recutita Flower Extract, Sophora Angustifolia Root Extract, Alcaligenes Polysaccharides.
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【Ingredient Analysis】
Activate Skin’s Natural Repair Mechanism | Ultra-Fine Microsphere PDRN
Formulated with 2100ppm high-concentration PDRN. Each microsphere is only 120nm in size and 1/800 of a pore, and carries up to 9,800 PDRN fragments. Using supramolecular microsphere encapsulation technology, PDRN is folded by peptides into nano-sized molecules and further wrapped in hyaluronic acid to form a highly stable, high-capacity 3D supramolecular microsphere. This structure effectively preserves PDRN activity while significantly enhancing skin penetration. It penetrates deep into the dermis within 1 hour, delivering active ingredients to activate the skin’s natural repair process. It helps repair damaged cells (including fibroblasts), soothe inflammation, strengthen the skin barrier, and stimulate collagen production.
Activate Skin’s Natural Repair Mechanism | Ultra-Fine Microsphere PDRN
Formulated with 2100ppm high-concentration PDRN. Each microsphere is only 120nm in size and 1/800 of a pore, and carries up to 9,800 PDRN fragments. Using supramolecular microsphere encapsulation technology, PDRN is folded by peptides into nano-sized molecules and further wrapped in hyaluronic acid to form a highly stable, high-capacity 3D supramolecular microsphere. This structure effectively preserves PDRN activity while significantly enhancing skin penetration. It penetrates deep into the dermis within 1 hour, delivering active ingredients to activate the skin’s natural repair process. It helps repair damaged cells (including fibroblasts), soothe inflammation, strengthen the skin barrier, and stimulate collagen production.
Based on laboratory testing:
✔ 427.34% skin penetration within 1 hour
✔ 68.72% improvement in cellular repair activity
✔ 47.95% reduction in the appearance of fine lines after 14 days
Centella Repair Base | 4X Centella Complex
Formulated with 85% Centella Asiatica Leaf Water in place of purified water, this soothing formula helps calm redness, reduce sensitivity, and strengthen the skin barrier.
✔ 427.34% skin penetration within 1 hour
✔ 68.72% improvement in cellular repair activity
✔ 47.95% reduction in the appearance of fine lines after 14 days
Centella Repair Base | 4X Centella Complex
Formulated with 85% Centella Asiatica Leaf Water in place of purified water, this soothing formula helps calm redness, reduce sensitivity, and strengthen the skin barrier.
- Asiaticoside: Helps rapidly soothe irritated skin, reduce inflammation, and relieve redness and sensitivity.
- Madecassoside: Supports the repair of damaged skin and promotes skin recovery, making it ideal for post-treatment or weakened skin.
- Asiatic Acid: Helps stabilize stressed skin while enhancing the skin's natural defense and resilience.
- Madecassic Acid: Strengthens the skin foundation, and helps smooth rough, uneven skin.
3-Layer Repair Structure | Activation, Support & Regeneration
- Ultra-Fine Microsphere PDRN: Delivers precise “repair signals” to activate fibroblasts, triggering natural collagen synthesis and cellular regeneration to restore skin vitality.
- Fibronectin: Helps maintain the structural integrity of the extracellular matrix (ECM), strengthening the skin’s foundational support. It creates a stable environment for skin repair while enhancing fibroblast activity and collagen production.
- Pro-Xylane: Stimulates the production of hyaluronic acid and glycosaminoglycans (GAGs), helping to rebuild the dermal-epidermal junction. It also supports the synthesis of Type IV and Type VII collagen, reinforcing skin elasticity and firmness.
Multi-Active & Soothing Complex | Strengthening & Soothing
- Ectoin: Forms a cellular hydration shield that acts like an invisible protective barrier against UV radiation, pollution, and oxidative stress. It also helps reduce inflammation, creating a stable environment for skin repair while strengthening barrier resilience.
- Vitamin B5: Soothes and repairs irritated skin. Supports skin barrier recovery while delivering long-lasting hydration.
- β-Glucans: An immune-modulating polysaccharide that helps activate skin immune cells, strengthen the skin barrier, and provide hydration.
- Gentian Root, Licorice Root, Dendrobium Officinale, Chamomile, and Sophora Root Extracts: A synergistic botanical complex that helps calm sensitive skin, reduce inflammation, relieve redness and discomfort.
Multi-Layer Moisture Base | Moisturizing & Hydration
- Sodium Hyaluronate: Stores large amounts of water. Provides long-lasting hydration and keeps skin soft and supple.
- Hydrolyzed Sodium Hyaluronate: Small size molecular HA that penetrates deeply into skin. Helps hydrate the skin and improves dryness and fine lines.
- Trehalose: A natural moisturizing factor (NMF), it helps retain moisture and reduces water loss.
- Glycerin: A natural moisturizing factor (NMF), it helps retain moisture to keep skin smooth and hydrated.
- Sodium Polyglutamate: Helps enhance water retention and maintain long-lasting hydration.
********************************************************************************【Usage】
After toner, apply evenly on face and neck. For dehydrated, red or post-procedures skin, the amount can be increased. It is recommended to drop directly onto the face and neck, gently spread until fully absorbed before applying serum, or mix with other serums prior to application. Do not use it in combination with acids or exfoliating products.
After toner, apply evenly on face and neck. For dehydrated, red or post-procedures skin, the amount can be increased. It is recommended to drop directly onto the face and neck, gently spread until fully absorbed before applying serum, or mix with other serums prior to application. Do not use it in combination with acids or exfoliating products.
1. Daily Care
Week 1: Apply 2 pumps on the face and 1 pump on the neck.
After Week 1: Apply 1 pump on the face and 0.5–1 pump on the neck.
*Do not use it with acids or Vitamin A products. Maintain at least a 10–12 hour interval.
*If acids or Vitamin A are used at night, apply PDRN Essence in the morning.
2. Intensive Rescue Care
Ideal for post-procedure, sensitivity, redness, breakouts, or sunburn. Apply 2 pumps or more on the face daily.
*During intensive repair, discontinue the use of acids and Vitamin A, apply PDRN Essence both morning and night.
【Recommended Serum Combinations】
PDRN Essence activates the cell renewal process and enhances the efficacy of subsequent serums. Do not use it in combination with acids or exfoliating serums, allow at least 10–12 hours between applications. It is recommended to use PDRN Essence in the morning, and apply acids or Vitamin A serums at night.
Anti-Aging: PDRN Essence + Collagen Ageless Firming Serum + Vitamin C Anti-Oxidant & Whitening Serum
Soothing: PDRN Essence + Calendula Soothing Serum
Anti-Acne: PDRN Essence + Lavender Anti-Acne Serum
Week 1: Apply 2 pumps on the face and 1 pump on the neck.
After Week 1: Apply 1 pump on the face and 0.5–1 pump on the neck.
*Do not use it with acids or Vitamin A products. Maintain at least a 10–12 hour interval.
*If acids or Vitamin A are used at night, apply PDRN Essence in the morning.
2. Intensive Rescue Care
Ideal for post-procedure, sensitivity, redness, breakouts, or sunburn. Apply 2 pumps or more on the face daily.
*During intensive repair, discontinue the use of acids and Vitamin A, apply PDRN Essence both morning and night.
【Recommended Serum Combinations】
PDRN Essence activates the cell renewal process and enhances the efficacy of subsequent serums. Do not use it in combination with acids or exfoliating serums, allow at least 10–12 hours between applications. It is recommended to use PDRN Essence in the morning, and apply acids or Vitamin A serums at night.
Anti-Aging: PDRN Essence + Collagen Ageless Firming Serum + Vitamin C Anti-Oxidant & Whitening Serum
Soothing: PDRN Essence + Calendula Soothing Serum
Anti-Acne: PDRN Essence + Lavender Anti-Acne Serum
********************************************************************************【Cautions】
Inedible. Avoid contact with eyes. Conduct allergy test or consult a physician before use. If discomfort occurs, rinse thoroughly with water. Keep in cool dry place.
Inedible. Avoid contact with eyes. Conduct allergy test or consult a physician before use. If discomfort occurs, rinse thoroughly with water. Keep in cool dry place.
